Description

Job Description

About the Program

The Vertex Physician Investigator (VPI) Program is a full-time, immersive opportunity for exceptional early-career physician-scientists who are passionate about solving unmet medical needs and advancing transformative science. Over two years, participants will complete four customized six-month rotations, receive intensive training, and benefit from direct mentorship by Vertex senior leaders.

This program is designed to provide a broad understanding of the drug development process and prepare participants for future leadership roles in biotechnology.

Program Highlights

Four Rotations Over Two Years

• Two mandatory rotations: Drug Discovery and Clinical Development
• Two elective rotations in other Vertex functions of the participant's choice

Training & Mentorship

• Intensive didactic training on the science and business of drug development
• Peer-to-peer learning and mentorship from Vertex senior leaders
• Career guidance and leadership development

Post-Program Opportunity

• Upon completion, participants will transition into a mutually selected full-time role at Vertex

Why Join Vertex as a Physician Investigator?

• Contribute to the development of transformative medicines
• Learn drug development from a leading biotech innovator
• Advance scientific ideas in a collaborative, team-based environment
• Leverage both clinical and research expertise
• Receive mentorship from scientific, medical, and business leaders
• Accelerate career growth and broaden exposure to diverse opportunities
• Develop leadership capabilities in a dynamic industry setting

Eligibility Requirements

• MD or MD/PhD with completed residency/fellowship
• ≤5 years post-residency/fellowship
• Demonstrated scientific and investigative impact (e.g., peer-reviewed publications, awards)
• Evidence of creative thinking, problem-solving, and innovation
• Willingness to work in Vertex's Boston office (relocation assistance available)
• Strong communication, teamwork, and leadership skills
• Interest in drug discovery, clinical research, and commercialization
• Ability to bring diverse perspectives and experiences to Vertex

Application Instructions

To apply, please submit your CV and a Cover Letter by January 9, 2026, 5:00 PM ET.

In your cover letter, consider addressing:

• Your most significant scientific or research achievement and how you accomplished it
• Why you are interested in pursuing a career in industry
• An example of how you applied creative thinking to solve a problem
• What you hope to gain from the Vertex Physician Investigator Program

Start Date: Summer-Fall 2026

Application Deadline: January 9, 2026, by 5:00 PM ET

Pay Range:
$188,000 - $282,000

Disclosure Statement:

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation:
Hybrid-Eligible Or On-Site Eligible

Flex Eligibility Status:

In this Hybrid-Eligible role, you can choose to be designated as:
1. Hybrid: work remotely up to two days per week; or select
2. On-Site: work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.

#LI-Hybrid

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com